114 128
Scott, L.J., Mohlke, K.L., Bonnycastle, L.L., Willer, C.J., Li, Y., Duren, W.L.,
Erdos, M.R., Stringham, H.M., Chines, P.S., Jackson, A.U., et al. (2007).
A genome-wide association study of type 2 diabetes in Finns detects multiple
susceptibility variants. Science
316
, 1341–1345.
Shang, L., Hua, H., Foo, K., Martinez, H., Watanabe, K., Zimmer, M., Kahler,
D.J., Freeby, M., Chung, W., LeDuc, C., et al. (2014).
b
-cell dysfunction due
to increased ER stress in a stem cell model of Wolfram syndrome. Diabetes
63
, 923–933.
Shimomura, K., Girard, C.A., Proks, P., Nazim, J., Lippiat, J.D., Cerutti, F.,
Lorini, R., Ellard, S., Hattersley, A.T., Barbetti, F., and Ashcroft, F.M. (2006).
Mutations at the same residue (R50) of Kir6.2 (KCNJ11) that cause neonatal
diabetes produce different functional effects. Diabetes
55
, 1705–1712.
Steinthorsdottir, V., Thorleifsson, G., Reynisdottir, I., Benediktsson, R.,
Jonsdottir, T., Walters, G.B., Styrkarsdottir, U., Gretarsdottir, S., Emilsson,
V., Ghosh, S., et al. (2007). A variant in CDKAL1 influences insulin response
and risk of type 2 diabetes. Nat. Genet.
39
, 770–775.
Unoki, H., Takahashi, A., Kawaguchi, T., Hara, K., Horikoshi, M., Andersen, G.,
Ng, D.P., Holmkvist, J., Borch-Johnsen, K., Jørgensen, T., et al. (2008). SNPs
in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian
and European populations. Nat. Genet.
40
, 1098–1102.
Wei, F.Y., Suzuki, T., Watanabe, S., Kimura, S., Kaitsuka, T., Fujimura, A.,
Matsui, H., Atta, M., Michiue, H., Fontecave, M., et al. (2011). Deficit of
tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes
in mice. J. Clin. Invest.
121
, 3598–3608.
Yamagata, K., Senokuchi, T., Lu, M., Takemoto, M., Fazlul Karim, M., Go, C.,
Sato, Y., Hatta, M., Yoshizawa, T., Araki, E., et al. (2011). Voltage-gated K+
channel KCNQ1 regulates insulin secretion in MIN6
b
-cell line. Biochem.
Biophys. Res. Commun.
407
, 620–625.
Yasuda, K., Miyake, K., Horikawa, Y., Hara, K., Osawa, H., Furuta, H., Hirota,
Y., Mori, H., Jonsson, A., Sato, Y., et al. (2008). Variants in KCNQ1 are asso-
ciated with susceptibility to type 2 diabetes mellitus. Nat. Genet.
40
, 1092–
1097.
Zhang, S., Liu, J., MacGibbon, G., Dragunow, M., and Cooper, G.J. (2002).
Increased expression and activation of c-Jun contributes to human amylin-
induced apoptosis in pancreatic islet beta-cells. J. Mol. Biol.
324
, 271–285.
340
Cell Stem Cell
19
, 326–340, September 1, 2016