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Figure 4. Reframed hiPSC-Derived Cardiomyocytes and Skeletal Muscle Cells Demonstrate Restored Function In Vitro and In Vivo

(A) Representative graphs of CK release assays from cells exposed to hypo-osmotic conditions. Cardiomyocytes and skeletal muscle myotubes derived from

hiPSCs were subjected to a range of osmolarities below 240 mosmol, and CK release to the supernatant was measured as an indication of membrane fragility.

Data are presented as average ± SE.

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538

Cell Stem Cell

18

, 533–540, April 7, 2016

ª

2016 Elsevier Inc.